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Hypoxia promotes metastasis and invasion of NSCLC. (a) Cellular wound healing assays of tumor cells (100x), N 21% O2, L 5% O2, S 1% O2; the results of wound healing assays. (b) Cell invasion was measured by Transwell assays (100x). The numbers of invading cells was counted from five fields of view in each group. (c) The mRNA level of VEGFR, FN1, and GLUT1 was detected by qRT-PCR.ns. P > 0.05, ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001.
