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. 2021 Apr 10;2021:5572140. doi: 10.1155/2021/5572140

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Copyright © 2021 Heng Zhang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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SXSM reduces Ang II-induced SAN dysfunction and increases heart rate in SSS mice. (a) Representative ECGs of mice in each group. (b) Mean heart rates in each group of mice. (c) Masson staining of the SAN of mice in each group. (d) Collagen volume fraction in the SAN of mice in each group. SHAM: mice with sham surgery; SSS: mice with Ang II treatment; SXSM: mice with Ang II and SXSM treatment; ^∗p < 0.05, ^∗∗p < 0.01. SAN, sinoatrial node; ECG, electrocardiogram; SXSM, Shenxian-shengmai oral liquid; SSS, sick sinus syndrome, Ang II, angiotensin II.