Table 2.
Frequencies of lncRNA GAS5 genotypes and alleles in IS patients and controls.
| Genotypes | IS patients, n = 1086 (%) | Controls, n = 1045 (%) | AOR (95% CI) | P value | P valuea |
|---|---|---|---|---|---|
| rs145204276 | |||||
| ins/ins(II) | 424 (39.0) | 486 (46.5) | 7.3 × 10−4 | 0.0020 | |
| ins/del(ID) | 528 (48.6) | 465 (44.5) | |||
| del/del(DD) | 134 (12.3) | 94 (9.0) | |||
| Dominant model DD+ID vs. II | 662 (61.0) | 559 (53.5) | 1.36 (1.14-1.61) | 5.0 × 10−4 | 0.0020 |
| Recessive model II+ID vs. DD | 952 (87.7) | 951 (91.0) | 0.70 (0.53-0.93) | 0.013 | 0.026 |
| ins allele | 1376 (63.4) | 1437 (68.8) | |||
| del allele | 796 (36.6) | 653 (31.2) | 1.27 (1.12-1.45) | 2.0 × 10−4 | 0.0016 |
| rs55829688 | |||||
| TT | 579 (53.3) | 517 (49.5) | 0.20 | 0.23 | |
| TC | 415 (38.2) | 430 (41.1) | |||
| CC | 92 (8.5) | 98 (9.4) | |||
| Dominant model TC+CC vs. TT | 507 (46.7) | 528 (50.5) | 0.86 (0.72-1.02) | 0.076 | 0.12 |
| Recessive model TT+TC vs. CC | 994(91.5) | 947(90.6) | 1.12(0.83-1.51) | 0.46 | 0.46 |
| T allele | 1573(72.9) | 1464(70.0) | |||
| C allele | 599(27.1) | 626(30.0) | 0.89(0.78-1.02) | 0.087 | 0.12 |
P value of difference in genotypes between the case group and control group. P < 0.05 is indicated in bold font. Adjusted for age, gender, smoking, hypertension, diabetes mellitus, and hyperlipidaemia. aFalse discovery rate-adjusted P value for multiple hypotheses testing using the Benjamini-Hochberg method. AOR: adjusted odds ratio; CI: confidence interval; DD: del/del; ID: ins/del; II: ins/ins; IS: ischemic stroke; lncRNA: long noncoding RNA.