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. 2021 Apr 20;227:108727. doi: 10.1016/j.clim.2021.108727

Fig. 3.

Fig. 3

The anti-EBV mechanisms of NK cells.

In peripheral blood, natural killer(NK) cells are activated by dendritic cells (DCs) to produce IFN-γ and increase cytotoxicity upon encountering IFN-α/β. IFN-γ prevents epstein-Barr virus (EBV) from entering B cells and prevent EBV-induced B cell malignant transformation.

In tonsils, CD56bright / NKG2A + NK cells prevent EBV-induced B cell malignant transformation in vitro by IFN-γ release and NKp44 engagement.