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. 2021 Apr 20;227:108727. doi: 10.1016/j.clim.2021.108727

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© 2021 Published by Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 4 — The anti-COVID-19 mechanisms of NK cells.

In coronavirus disease 2019 (COVID-19), natural killer (NK) cells activated by tumour necrosis factor (TNF)-α and IL-6, et al., migrate to lungs and release cytokines, such as IFN-γ. The antibody dependent cell-mediated cytotoxicity (ADCC) via severe acute respiratory syndrome coronavirus (SARS-CoV)-2 S-glycoproteins triggers NK cell killing of infected cells .The activating receptors on NK cells recognize the ligands on infected cells, activating NK cells.