Table 1.
Summary of Basic Patient Demographics, With a Breakdown of SUVpeak, Conventional Planar Quantification, and Heart/CL Ratio Results by DPD Perugini Grade
| Grade 0 (n = 40) | Grade 1 (n = 12) | Grade 2 (n = 41) | Grade 3 (n = 7) | p Value | |
|---|---|---|---|---|---|
| Demographic characteristics | |||||
| Male | 12 (30) | 9 (75) | 27 (66) | 4 (57) | 0.003 |
| Age | 86 ± 5 | 83 ± 12 | 82 ± 10 | 80 ± 8 | 0.11 |
| Amyloid type∗ | |||||
| Likely wild-type ATTR | – | 9 (82) | 24 (66) | 1 (17) | 0.03 |
| Variant ATTR | – | 0 (0) | 11 (31) | 5 (83) | 0.001 |
| AL amyloid | – | 2 (18) | 1 (3) | 0 (0) | 0.14 |
| SUVpeak | |||||
| Cardiac | 1.0 ± 0.4 | 3.7 ± 1.5 | 11.9 ± 3.8 | 10.6 ± 1.5 | <0.001 |
| Paraspinal | 0.6 ± 0.1 | 0.9 ± 0.2 | 1.0 ± 0.3 | 1.3 ± 0.3 | <0.001 |
| Vertebral | 8.4 ± 1.5 | 7.2 ± 1.2 | 6.2 ± 1.9 | 4.6 ± 0.1 | <0.001 |
| Hepatic | 0.6 ± 0.2 | 0.6 ± 0.2 | 0.6 ± 0.3 | 0.5 ± 0.2 | 0.87 |
| SUV retention index | 0.07 ± 0.03 | 0.48 ± 0.28 | 2.04 ± 0.82 | 3.24 ± 1.04 | <0.001 |
| Conventional planar | |||||
| WB retention | 74.5 ± 7.8 | 81.2 ± 6.6 | 83.2 ± 7.0 | 90.3 ± 4.6 | <0.001 |
| Heart retention | 3.6 ± 0.8 | 4.6 ± 0.9 | 6.0 ± 1.4 | 6.7 ± 0.9 | <0.001 |
| Heart/WB ratio | 4.9 ± 0.9 | 5.7 ± 0.9 | 7.2 ± 1.6 | 7.4 ± 1.1 | <0.001 |
| H/CL ratio | 1.01 ± 0.10 | 1.35 ± 0.21 | 2.23 ± 0.55 | 2.12 ± 0.59 | <0.001 |
Values are n (%) or mean ± SD.
H/CL = heart/contralateral lung; DPD = 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid; SUVpeak = peak standardized uptake value; WB = whole-body.
∗
7 patients were excluded due to no diagnostic work-up results being available at the time of submission; percentages quoted reflect this. Transthyretin genotyping was available in 70% of the transthyretin-related cardiac amyloidosis (ATTR-CA) population. Bold values p value <0.05.