Table 3.
Table characteristics of non-comparative observational (no placebo) studies
| Reference | Study period | Study design | Number of rtPA patients with LACI | Stroke classification | Median NIHSS improvement# | % of mRS 0-1 | % of mRS 0–2 | % of sICH | % of mortality |
|---|---|---|---|---|---|---|---|---|---|
| Chang et al. [28] | 2007–2010 | Observational; retrospective; single-center | 39 | TOAST | 1.6$ | – | – | 4 | – |
| Sung et al. [29] | 2003–2012 | Observational; retrospective; single-center | 22 | OCSP | – | – | 81.8 | 4.5 | 0 |
| Lee et al. [30] | 1999–2008 | Observational; retrospective; single-center | 23 | OCSP | – | – | – | 0 | – |
| Fluri et al. [31] | −2007 | Observational; retrospective; multicenter | 65 | TOAST | – | – | 75.4 | 4.6 | 1.5 |
| Kohrmann et al. [32] | 2006–2008 | Observational; retrospective; single-center | 12 | TOAST | – | – | – | 0 | – |
| Padma et al. [33] | 2002–2006 | Observational; prospective; single-center | 22 | TOAST | – | – | – | 0 | – |
| Cocho et al. [34] | 1997–2004 | Observational; retrospective; single-center | 11 | OCSP | – | 27.2 | 54.5 | 0 | 0 |
| Miedema et al. [35] | 2002–2013 | Observational; retrospective; multicenter | 162 | OCSP | – | – | 78 | 1.9 | – |
| Simonsen et al. [36] | 2004–2010 | Observational; retrospective; single-center | 115 | TOAST | – | – | – | 0 | – |
| Pan et al. [37] | 2007–2014 |
Observational; retrospective; multicenter |
82 | TOAST | – | – | – | 1.2 | 0 |
| Zivanovic et al. [38] | 2009–2016 |
Observational; prospective; single-center |
46 | OCSP | – | 76.1 | 82.6 | 0 | 2.2 |
| Kim et al. [39] | 2010–2016 |
Observational; retrospective; single-center |
25 | TOAST | – | 52 | – | 0 | – |
rtPA: recombinant tissue plasminogen activator: mRS: modified Rankin Scale; sICH: symptomatic intracerebral hemorrhage; LACI: lacunar infarct; TOAST: The Trial of Org 10,172 in Acute Stroke Treatment; OCSP: The Oxfordshire Community Stroke Project; #: Δinitial-discharge; $: mean difference in discharge NIHSS