Table 3.
Baseline echocardiographic and laboratory parameters of patients with light chain amyloidosis (n = 58) with and without pleural effusion* (extracted)
| No pleural effusion (n = 33) | Pleural effusion (n = 25) |
p-value | |
|---|---|---|---|
| Echocardiography parameters | |||
| LA length mm | 60.0 (56.0–67.0) | 60.0 (52.0–64.0) | 0.665 |
| LVEDD, mm | 46.0 (43.0–48.0) | 35.0 (32.0–46.0) | < 0.001 |
| LVEF, % | 61.0 (51.0–70.0) | 56.0 (46.0–65.0) | 0.626 |
| LV-GLS, -% | 14.8 (19.10–14.0) | 11.3 (14.8–8.3) | 0.003 |
| IVS, mm | 16.0 (14.0–18.0) | 19.0 (16.0–22.0) | 0.170 |
| RV diameter, mm | 34.0 (30.0–37.0) | 30.0 (26.0–36.0) | 0.044 |
| RA length, mm | 59.0 (51.0–64.0) | 58.0 (52.0–61.0) | 0.826 |
| RV strain basal, -% | 16.5 (20.0–14.0) | 13.0 (18.0–11.0) | 0.009 |
| RV strain mid, -% | 18.0 (21.0–15.0) | 14.0 (17.0–11.0) | 0.007 |
| RV strain apical, -% | 19.0 (23.0–15.0) | 14.0 (18.0–12.0) | 0.013 |
| RV- GLS, -% | 18.0 (21.3–15.0) | 14.0 (17.7–11.0) | 0.007 |
| RV- TDI, m/s | 0.14 (0.13–0.16) | 0.11 (0.09–0.12) | 0.009 |
| TAPSE, mm | 18.0 (15.0–22.0) | 14.0 (13.0–16.0) | 0.001 |
| TR velocity, m/s | 3.0 (2.6–3.7) | 2.8 (2.6–3.1) | 0.251 |
| sPAP, mmHg | 51.0 (35.0–67.0) | 42.5 (39.0–50.0) | 0.354 |
| IVC diameter, mm | 19.0 (14.0–25.0) | 19.0 (18.0–23.0) | 0.594 |
| Laboratory parameters | |||
| NT-pro BNP, pg/mL | 2292.0 (1121.0–4118.0) | 8866.0 (4751.0–17,103.0) | < 0.001 |
| Troponin T, ng/L | 41.0 (21.0–73.5) | 112.0 (65.0–232.0) | 0.001 |
| Gamma GT, U/L | 36.0 (21.0–77.0) | 117.0 (56.0–194.0) | < 0.001 |
| ASAT, U/L | 23.0 (18.0–28.0) | 27.0 (20.0–43.0) | 0.094 |
| ALAT, U/L | 21.0 (17.0–26.0) | 22.0 (15.0–43.0) | 0.994 |
| Albumin, U/L | 39.2 (30.6–42.6) | 33.9 (28.5–40.3) | 0.253 |
| CRP, mg/dl | 0.2 (0.1–1.0) | 0.9 (0.3–1.9) | 0.021 |
| eGFR, mL/min/1.73m2 | 47.8 (33.3–61.5) | 40.5 (22.7–55.9) | 0.316 |
| Cardiac magnetic resonance imaging parameters | |||
| IVS, mm | 14.0 (12.0–26.0) | 19.0 (15.0–21.0) | 0.005 |
| LVEF, % | 63.0 (53.0–66.0) | 61.0 (57.0–65.0) | 0.572 |
| LV-ECV, % | 40.0 (32.0–43.0) | 48.0 (41.0–59.0) | 0.003 |
| RVEF, % | 57.0 (48.0–62.0) | 56.0 (45.0–5620) | 0.405 |
Continuous variables are given in mean and interquartile range
LA indicates left atrium, LVEDD left ventricular end-diastolic diameter, LVEF left ventricular ejection fraction, IVS interventricular septum, RV right ventricle, RA right atrium, RV-GLS right ventricular global longitudinal strain, TDI tissue Doppler index, TAPSE tricuspid annular plane systolic excursion, TR tricuspid regurgitation, sPAP systolic pulmonary artery pressure, IVC inferior vena cava, NT-pro BNP N-terminal pro brain natriuretic peptide, Gamma GT gamma glutamyltransferase, ASAT aspartate aminotransferase, ALAT alanine aminotransferase, CRP C-reactive protein, eGFR estimated glomerular filtration rate calculated by the modification of diet in renal disease (MDRD) formula, LV-ECV left ventricular extra cellular volume, RVEF right ventricular ejection fraction