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. 2021 Jan 30;99(5):699–711. doi: 10.1007/s00109-021-02036-8

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© The Author(s) 2021

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Fig. 3 — The glucocorticoid effect on serum FGF23 and bone Fgf23 expression. Arithmetic means ± SEM of the serum concentration of C-terminal FGF23 (a, n = 11) and intact FGF23 (b, n = 13) as well as relative osseous mRNA expression (c) of Fgf23 (n = 7, arbitrary units (a. u.), Dmp1 (n = 9), Phex (n = 9), and Nfkbia (n = 9) normalized to housekeeping gene Gapdh in control mice (ctr, white bars) and dexamethasone-treated mice (20 mg/kg body weight, DEXA, black bars) 12 h after injection. Arithmetic means ± SEM of the serum concentration of C-terminal (d, n = 10) and intact FGF23 (e, n = 10) in mice 12 h after treatment with vehicle (ctr, white bars) or prednisolone (20 mg/kg body weight; black bars). *p < 0.05, **p < 0.01 indicate significant difference compared to vehicle-treated mice. (a, c (right lower panel) and e: unpaired t test with Welch’s correction; b and c (right upper panel): unpaired t test; c (left upper panel and left lower panel) and d: Mann-Whitney U test)