Fig. 3.

Mice with fibroblast-specific deletion of Gata4 and Gata6 show a reduced capillary density after pressure overload. a–c Quantification of cardiac fibrosis from transverse mouse heart sections stained with Sirius-red after short (a) and long (b) pressure overload and representative pictures of Sirius-red stained hearts (c), scale bar 1 mm. d, e Quantification of the cardiomyocyte cross-sectional area after short (d) and long (e) pressure overload. f–h Quantification of the capillary density displayed as capillary per cardiomyocyte ratio after short (f) and long (g) pressure overload and representative pictures of WGA and IsolectinB4 stained heart sections (h), scale bar 50 µm. Data are shown as mean ± SD. Two-way ANOVA with Sidak’s multiple-comparisons test was used to test for statistical significance. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001