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. 2021 Apr 19;116(1):26. doi: 10.1007/s00395-021-00862-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Transcriptome analysis of isolated cardiac fibroblasts showing an upregulation of anti-angiogenic genes in cells with Gata4/Gata6 deletion compared to control cells. a Heatmap of differentially regulated genes showing all analyzed groups (left panel) and direct comparison of Gata6fl-βGal (control) vs. Gata4/6fl-Cre (right panel) isolated cardiac fibroblast samples (n = 3 in each group). Gene ontology (GO, biological process) classification and selected example genes are demonstrated on the right. Bioinformatic analysis of RNA-Seq data is described in the “Materials and methods” section. b Venn diagram of significantly upregulated genes in fibroblasts with Gata4, Gata6, and Gata4/6 deletion compared to Gata6fl-βGal control samples. c RNA expression level of selected anti-angiogenic genes from RNA-sequencing. d Visualization of the top 20 GO BP clusters and relationships as a network plot. Each node represents an enriched term and is colored depending on its cluster ID, the cluster ID legend is shown on the right. Terms with a similarity > 0.3 are connected by edges. Data are shown as mean ± SD. Student’s t test was used for comparison of two groups. *p < 0.05, ***p < 0.001