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. 2021 Apr 15;2(3):zqab019. doi: 10.1093/function/zqab019

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© The Author(s) 2021. Published by Oxford University Press on behalf of American Physiological Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — One-Week Xenobiotic Pretreatment Attenuates Energy Expenditure by the Cecum. (A) Body mass. (B) Total heat dissipation determined by direct calorimetry, under general anesthesia. (C) Estimated marginal mean heat dissipation at mean body mass of 25.72g. P_Model<.001, P_BodyMass<.001, P_Risperidone=.010, R²=0.596. (D) Example tracing of total heat dissipation, illustrating time course of cecectomy experiment. (E) Cecum mass. (F) Change in heat dissipation immediately following cecectomy. (G) Estimated marginal mean change in heat dissipation immediately following cecectomy at mean cecum mass of 0.3888g. P_Model=.049, P_CecumMass=.282, P_Risperidone=.016, R²=0.231. For all panels, n = 12 vehicle and n = 14 risperidone-treated male C57BL/6J mice. *P < .05 by independent t-test (B–D, F) or Tukey multiple comparisons procedure (E). Summary data are presented as mean ± SE.