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. 2021 Apr 12;13:3155–3169. doi: 10.2147/CMAR.S292461

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© 2021 Huang et al.

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Inhibition of the Nrf2/HO-1 axis decreased the expression of VEGF. (A–D) Western blotting analyzed the effect of BRU on the protein expression of Nrf2, HO-1, and VEGF in BGC-823 cells. BGC-823 cells were treated as follows: control, 0.1% DMSO, and 10, 20, 40, 80, or 100 nM BRU for 24 h under hypoxic conditions. (E–G) qPCR analyzed the effect of BRU on the mRNA expression of Nrf2, HO-1, and VEGF in BGC-823 cells. BGC-823 cells were treated as follows: control, 0.1% DMSO, or 40 nM BRU for 24 h under hypoxic conditions.

Notes: *P<0.05, **P<0.01.

Abbreviation: ns, no signiﬁcance.