Table 2.

Predicted Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways with a significant different relative abundance between high- vs. low-fatigue groups (p < 0.0005)

KEGG orthology (KO) pathways	Pre		Post		P
	Low fatigue	High fatigue	Low fatigue	High fatigue
ko04011: MAPK signaling pathway	3.83 × 10−4	4.11 × 10−4	4.16 × 10−4	4.19 × 10−4	0.0005
ko00020: citrate cycle TCA cycle	4.70 × 10−3	5.17 × 10−3	4.84 × 10−3	5.39 × 10−3	0.0003
ko00730: thiamine metabolism	1.00 × 10−2	7.65 × 10−3	9.40 × 10−3	7.91 × 10−3	0.0003
ko04510: focal adhesion	1.27 × 10−5	1.26 × 10−5	1.27 × 10−5	1.62 × 10−5	0.0003
ko05212: pancreatic cancer	1.8 × 10−6	2.27 × 10−6	1.22 × 10−6	7.85 × 10−6	0.0003
ko04720: long-term potentiation	5.60 × 10−7	7.70 × 10−7	4.20 × 10−7	2.67 × 10−6	0.0002
ko00350: tyrosine metabolism	5.26 × 10−3	4.64 × 10−3	5.14 × 10−3	4.74 × 10−3	< 0.0000
ko00624: polycyclic aromatic hydrocarbon degradation	2.78 × 10−3	2.24 × 10−3	2.52 × 10−3	2.22 × 10−3	< 0.0000
ko00740: riboflavin metabolism	3.67 × 10−3	4.19 × 10−3	3.87 × 10−3	4.33 × 10−3	< 0.0000

MAPK mitogen-activated protein kinase, TCA tricarboxylic acid