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. 2020 Dec 23;37(4):478–496. doi: 10.1007/s12264-020-00617-0

Fig. 1.

Fig. 1

Deficiency of Ttyh1 attenuates the basal nociception and pain hypersensitivity associated with peripheral inflammation. A, B Paw withdrawal mechanical threshold (PWMT) and paw withdrawal thermal latency (PWTL) in basal pain perception (n = 10 mice). C Spontaneous pain induced by capsaicin (n = 6 mice). D, E Time course (D) and quantitative summary (E) of formalin-induced spontaneous pain (n = 5 mice). F Representative traces showing the response curves of basal and CFA-induced mechanical pain hypersensitivity at different time points after CFA injection (n = 10 mice). G Quantitative summary of the drop in PWMT to von Frey filament stimuli after CFA injection (n = 10 mice). H Quantitative summary of the drop in PWTL to radiant heat stimuli after CFA injection (n = 10 mice). I Motor function does not change with Ttyh1 deficiency (P > 0.05, n = 6 mice). All data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, †P < 0.05 vs Ttyh1+/+ mice at the same time point.