Table 3.
Status of the antioxidative enzymes in the colon of DMH and EPS-treated rats
| S. no | Parameter | Normal control (Group I) | Only DMH (Group II) | Standard 5-FU (Group III) | EPS 200 mg/kg b.w (Group IV) | EPS 400 mg/kg b.w (Group V) |
|---|---|---|---|---|---|---|
| 1 | SOD units/min/mg | 5.55 ± 0.53 | 2.86 ± 0.24* | 6.06 ± 0.20 | 3.78 ± 0.18* | 4.66 ± 0.24 |
| 2 | Catalase μmole/min/mg | 88.33 ± 4.13 | 52.33 ± 2.33** | 89.33 ± 3.77 | 67.00 ± 2.36* | 77.00 ± 2.36 |
| 3 | LPO nM of MDA/mg | 89.96 ± 56.46 | 64.81 ± 6.51** | 101.15 ± 17.76 | 95.81 ± 6.50 | 83.31 ± 52.72 |
| 4 | GPx μmoles/min/mg | 43.50 ± 2.25 | 21.83 ± 1.72** | 48.83 ± 1.94 | 33.50 ± 2.58* | 39.83 ± .94 |
| 5 | GSH μg/mg | 31.00 ± 1.26 | 14.83 ± 1.72** | 37.83 ± 1.47 | 20.83 ± 1.16* | 31.33 ± 1.63 |
| 6 | Vitamin C μg/mg | 1.15 ± 0.14 | 0.33 ± 0.06* | 1.13 ± 0.13 | 0.72 ± 0.06 | 0.92 ± 0.15 |
In all the cases the amount of antioxidants/antioxidative enzyme is reduced in the cancer control rats (Group II) which is brought to near normal levels by the treatment with EPS (Group IV and V)
*p < 0.05
**p < 0.01