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. 2021 Feb 2;37(4):497–510. doi: 10.1007/s12264-020-00626-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — miR-7239-3p inhibitor reversed the tumor-promoting effects of M2 phenotype microglial exosomes. A Cell apoptosis and cell cycle of GL261 were detected by FCM following PI staining. The abscissa represents Annexin V, and the ordinate represents PI. B FCM results of Apoptosis. C, D FCM results of cell cycle. The abscissa of D represents the DNA content and the ordinate represents the number of effective cells. E The statistical results of the colony number in each group. F The statistical result of the number of cells penetrating the chamber in each group. G The statistical results of CCK8 assay for cell survival. H The formed clones of GL261 cells after crystal violet staining. I The microscopic image of GL261 cells penetrating the chamber after crystal violet staining (×100). J The microscopic image of GL261 cell scratch experiments. K The relative expression levels of Bmal1 and miR-7239-3p RNA in the two groups were detected by real-time qPCR. The internal reference protein is β-actin. L The statistical results of cell scratch experiments. The vertical axis represents the wound healing percentage. M Protein bands of relevant proteins in the two groups were detected by Western blot. N Quantitative analysis of protein expressions (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001.