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. 2020 Dec 23;37(4):550–562. doi: 10.1007/s12264-020-00621-4

Fig. 3.

Fig. 3

Expression of pERK, pp38, and pro-inflammatory cytokines induced by pIONL is attenuated in the TG of Tlr8−/− mice. A, B Phosphorylation of ERK and p38 is increased at 10 days after pIONL in the TG of WT mice (*P < 0.05, **P < 0.01 vs sham, Student’s t-test; n = 3 mice/group). C, D The phosphorylation of ERK and p38 induced by pIONL is reduced in the TG of Tlr8−/− mice (*P < 0.05, vs WT, Student’s t-test; n = 3 mice/group). E–G The expression of TNF-α (E), IL-1β (F), and IL-6 (G) is increased by pIONL in the TG of WT mice. The fold-increase of TNF-α (E), IL-1β (F), and IL-6 (G) induced by pIONL is lower in Tlr8−/− mice than in WT mice (*P < 0.05, **P < 0.01, ***P < 0.001, pIONL vs sham; #P < 0.05, Tlr8−/− vs WT-pIONL, Student’s t-test; n = 5–6 mice/group).