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. 2020 Dec 23;37(4):550–562. doi: 10.1007/s12264-020-00621-4

Fig. 6.

Fig. 6

The TLR8 agonist VTX-2337-induced upregulation of pERK, pp38, and pro-inflammatory cytokines is reduced in Tlr8−/− mice. A, B After intra-TG injection of VTX-2337, the phosphorylation of ERK and p38 is increased in the TG of WT mice (*P < 0.05, **P < 0.01 vs PBS, Student’s t-test; n = 3 mice/group). C, D The phosphorylation of ERK and p38 in the TG does not increase after intra-TG injection of VTX-2337 in Tlr8−/− mice (P > 0.05 vs PBS, Student’s t-test; n = 3 mice/group). E–G The expression of TNF-α (E), IL-1β (F), and IL-6 (G) is increased by intra-TG injection of VTX-2337. The fold-increase of TNF-α (E), IL-1β (F), and IL-6 (G) induced by VTX-2337 is lower in Tlr8−/− mice than in WT mice (**P < 0.01, ***P < 0.001 vs WT-PBS; #P < 0.05, ##P < 0.01 vs WT-VTX-2337 group, Student’s t-test; n = 5 mice/group).