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. 2021 Feb 19;37(4):440–460. doi: 10.1007/s12264-021-00640-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Expression of IPC-specific marker genes and their lineage progression. A-F Feature plots of marker genes for RGCs, aMIPCs, bMIPCs, and OL-lineage, AS-lineage, OBiN-lineage cells. Broad cell types (cell lineages) are shown rather than individual clusters. Note a small number of cells between RGCs and AS-lineage cells (arrows in B); they might be RGCs that were translocating to the cortex. Also note the gradual downregulation of Ascl1, Egfr, and Olig2/1 expression in AS-Iineage cells (arrowheads in B). G Predicted cell lineage trajectories from RGCs. H-J Schematic of the aMIPC and bMIPC lineage progression.