Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 19;37(4):440–460. doi: 10.1007/s12264-021-00640-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 8 — Delineation of cell types in E18.5 cortex and identification of master regulators of the OBiN-lineage. A Seventeen clusters (C0-C16) identified and annotated according to marker gene accessibility (scATAC-seq was performed on GFP⁺ cells from the E18.5 cortex of hGFAP-GFP transgenic mice). B Genome tracks showing normalized accessibility for marker genes with cluster-specific accessibility in their promoter and gene body. C UMAP plots showing distinct chromatin accessibility profiles of marker genes. D Scheme for construction of the developmental trajectory. E Enrichment analysis for transcription factor motifs in the OBiN-lineage showing that GSX2 and DLX1/2 bind to the VISTA enhancers of Dlx1/2, Dlx5/6 and Sp8/9. The height of the letters (right panel) represents the frequency of each base in the cognate motif.