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. 2021 Apr 6;12:662892. doi: 10.3389/fmicb.2021.662892

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Copyright © 2021 Zou and Imperiale.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Polyomavirus genome map and mechanism of miRNA expression. The dsDNA genome is depicted by the two circles. Inner circle indicates early coding strand; outer circle indicates late coding strand. The locations of the early and late genes are indicated by the thick arrows on the circles. The viral miRNA coding region is indicated as a blue bar: its exact position varies from virus to virus, but it is always complementary to the early region mRNA. NCCR: non-coding control region. Lower left shows miRNA being expressed from the NCCR with processing from an intron derived from tandem transcripts circling more than once. miRNA could also be directly expressed from a primary transcript derived from the NCCR. Lower right shows miRNA expressed from an independent promoter upstream of the miRNA coding region. Forward arrows indicate promoters. LL, leader sequence.