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. 2021 Apr 6;8:660688. doi: 10.3389/fmed.2021.660688

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Copyright © 2021 Barreira, Lourenço, Calisto, Moreira-Gonçalves, Santos and Videira.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Forest plots for length of hospitalization analysis and sub-analysis assessing CP intervention and standard treatment. (A) Beginning at hospital admission, the hospitalization length results showed a significantly decreased period of hospital stay for the standard treatment. However, the overall heterogeneity levels are high; therefore, we conducted a sub-analysis. (B) Sub-analysis by disease severity (miscellaneous of critical and severe patients, and moderately ill patients). (C) Sub-analysis by study design (RCTs vs. CNRTs). (D) Sub-analysis by administration period of CP (before or after 7 days of hospitalization). The results are presented in mean and standard deviation (SD). Different sizes of data markers correspond to the relative weight assigned in the pooled analysis. Diamond marker indicates the overall result.