TABLE 1.

Experimental data and characteristics of rats subjected to BL and HS.

	Con		HS
	PBS (n = 8 ∼ 10)	BL (n = 8 ∼ 10)	PBS (n = 8 ∼ 10)	BL (n = 8 ∼ 10)
BW pre-gavage, g	266.4 ± 14.43	266.4 ± 13.81	265.3 ± 11.63	265.4 ± 11.09
BW post-gavage, g	309.8 ± 11.01	317.5 ± 12.19	308.2 ± 11.91	319.4 ± 9.91
BW post-heating, g	–	–	285.6 ± 12.48	308.7 ± 11.33
BW lose-heating, g	–	–	12.6 ± 2.38	10.7 ± 2.65
Tc max, °C	–	–	43.1 ± 0.46	42.0 ± 0.58#
Time of HS onset, min	–	–	96.9 ± 6.51	113.3 ± 11.09#
ALT, U/L	25.2 ± 8.59	24.5 ± 6.47*	127.9 ± 36.17*	79.8 ± 15.6#
AST, U/L	81.8 ± 10.99	80.3 ± 11.44*	322.6 ± 60.27*	146.9 ± 34.07#
BU, mol/L	4.8 ± 2.26	5.3 ± 0.98*	19.5 ± 5.50*	14.2 ± 2.90#
CREA, μmol/L	6.7 ± 1.77	8.2 ± 1.44*	58.2 ± 18.17*	27.5 ± 7.054#
CK, U/L	291.3 ± 172.90	462.2 ± 116.10*	1631 ± 1002.00*	808.9 ± 336.60#
TNF-α, pg/ml	1.5 ± 0.31	1.1 ± 0.66*	3.3 ± 0.65*	1.8 ± 0.41#
IL-1β, pg/ml	5.9 ± 4.39	8.6 ± 4.54*	34.7 ± 6.69*	28.1 ± 3.94#
IL-6, pg/ml	4.0 ± 2.92	3.2 ± 1.92*	40.7 ± 10.87*	20.8 ± 4.41#
D-Lactate, μmol/mL	0.2 ± 0.03	0.2 ± 0.041*	0.7 ± 0.13*	0.3 ± 0.03#
I-FABP, pg/mL	216.3 ± 80.17	212.7 ± 63.04*	754.7 ± 266.2*	368.9 ± 117.3#
Endotoxin, EU/mL	0.1 ± 0.01	0.1 ± 0.01*	0.8 ± 0.13*	0.6 ± 0.13#
FITC-4kD, μmol/mL	0.1 ± 0.03	0.1 ± 0.04*	1.8 ± 0.86*	0.9 ± 0.43#

Data are shown as means ± SD; sample sizes are indicated in (n); BW, body weight; Tc max, mean value and SD of the maximum Tc during the heating period. Time of HS onset, the time from the beginning of heating to Tc reaching the standard of HS onset or to the end of the heating period in the BL group. ALT, alanine aminotransferase; AST, aspartate aminotransferase; BU, blood urea; CK, creatine kinase; CREA, creatinine; I-FABP, intestinal fatty acid-binding protein; FITC-4kD, 4-kDa fluorescein isothiocyanate. * vs. Con + PBS; ^# vs. HS + PBS.