Figure 1.

More widespread network disruptions in task-based condition than task-free condition in stroke patients. (A) (Left panel) Significant interaction effects of group (patients vs controls) and task (rest vs task) were found in intra-network FC within default and DorsAttn networks and in inter-network FC between default and DorsAttn, control and DorsAttn, SalVenAttn and subcortical networks. (Right panel) Compared to age-matched healthy controls, stroke patients showed lower intra-network FC in control, SalVenAttn, and subcortical networks as well as lower inter-network FC between ipsilesional control and bilateral subcortical networks during the task-free condition. During the task-general condition, stroke patients had more widespread network disruptions than resting-state, including lower intra-network FC in default, control, SalVenAttn, SomMot, and subcortical networks. Additionally, lower inter-network FC was found between ipsilesional default and other contralesional networks (except limbic and subcortical), ipsilesional control and other contralesional networks (except limbic, visual, and TempPar), as well as contralesional SalVenAttn and bilateral SomMot and subcortical networks. (B) The average FC of edges showing significant interaction effect for four representative networks impaired based on NBS statistics in panel (A) were shown. Data are presented as mean ± standard error. C contralesional, DorsAttn dorsal attention, FC functional connectivity, I ipsilesional, NBS network-based statistics, SalVenAttn salience/ventral attention, SomMot somatomotor, TempPar temporoparietal.