Table 2.
Changes in Levels of complement factors and cytokines in the aqueous humor-patients and controls.
| Controls (n = 30) | P (Controls vs Baseline) | Eyes with CNV (n = 72) | |||
|---|---|---|---|---|---|
| Baseline | 2 months | P (Baseline vs 2 months) | |||
| C3a, median (IQR) (pg/mL) |
1929 (1374–3010) |
0.033 |
2480 (1862–3433) |
3095 (2524–4464) |
< 0.001 |
| C4a, median (IQR) (pg/mL) |
1278 (836–1638) |
0.021 |
1545 (1146–1919) |
1633 (1353–2153) |
< 0.001 |
| VEGF, median (IQR) (pg/mL) |
23.79 (16.34–35.11) |
0.016 |
36.68 (20.90–51.50) |
8.57 (4.31–18.29) |
< 0.001 |
| MCP1, median (IQR) (pg/mL) |
174.8 (116.1–260.3) |
0.002 |
252.6 (178.8–382.8) |
262.4 (193.1–331.3) |
0.570 |
The data were analyzed using the Mann–Whitney U-test; the eyes with CNV and controls, and baseline and at 2 months. C3a, complement component 3a; C4a, complement component 4a; VEGF, vascular endothelial growth factor; MCP-1, macrophage chemoattractant protein 1. IQR, interquartile range.