Table 3.
Changes in Levels of complement factors and cytokines in the aqueous humor of patients with CNV.
| Analyte median (IQR) (pg/mL) |
PNV (n = 22) | PCV (n = 25) | DA nAMD (n = 25) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | 2 months | P | Baseline | 2 months | P | Baseline | 2 months | P | |
| C3a |
2059 (1853–3171) |
3406 (2194–4760) |
0.017 |
2668 (1886–3932) |
3084 (2701–4956) |
0.187 |
2539 (1811–3319) |
3047 (2453–3748) |
< 0.001 |
| C4a |
1518 (971–2066) |
1683 (1494–1889) |
0.003 |
1601 (1192–2133) |
1762 (1252–2546) |
0.804 |
1503 (1147–1832) |
1594 (1231–2184) |
< 0.001 |
| VEGF |
35.67 (25.03–47.27) |
08.39 (6.34–16.32) |
< 0.001 |
38.73 (20.47–65.93) |
12.90 (04.31–22.44) |
< 0.001 |
36.07 (18.45–52.21) |
6.96 (4.06–17.61) |
0.011 |
| MCP1 |
223.8 (131.1–386.8) |
203.0 (117.3–315.8) |
0.649 |
314.2 (231.4–476.9) |
265.1 (192.9–327.9) |
0.023 |
266.6 (179.1–291.4) |
289.1 (226.1–344.1) |
0.045 |
Changes in levels of complement factors and cytokines in the aqueous humor of eyes with choroidal neovascularization (CNV). Wilcoxon signed rank test was used for comparisons between baseline and 2 months.
nAMD, neovascular age-related macular degeneration; PNV, pachychoroid neovasculopathy; PCV, polypoidal choroidal vasculopathy; DA nAMD, drusen associated neovascular age-related macular degeneration; IQR, interquartile range; C3a, complement component 3a; C4a, complement component 4a; VEGF, vascular endothelial growth factor; MCP-1, macrophage chemoattractant protein 1. The Mann–Whitney U-test was used for analysis between baseline and 2 months.