Skip to main content
. 2021 Apr 19;12:2311. doi: 10.1038/s41467-021-22399-3

Fig. 5. SERPINA5 gene expression changes differ among AD subtypes and track with advanced neurofibrillary tangle pathology.

Fig. 5

a, b SERPINA5 expression increases in a monotonic fashion among AD subtypes in the RNA-Seq cohort (a), which was replicated in the larger NanoString cohort (b). c SERPINA5 gene expression from NanoString cohort associates with % burden of advanced tangle maturity marker Ab39 using two-sided Pearson correlation analysis. d Immunohistochemical investigation of SERPINA5 in controls (n = 10) and among AD subtypes (n = 20 per subtype) reveals a monotonic increase in hippocampal subsectors and a monotonic decrease in the association cortices. Pair-wise comparisons for graphs can be found in Supplementary Fig. 2. Scale bar represents 100 µm. AD, Alzheimer’s disease; Aβ, amyloid-β; HpSp, hippocampal sparing; Limbic, limbic predominant; RNA-Seq, RNA sequencing. Note: control cases = green, hippocampal sparing AD = red, typical AD = gray, limbic predominant AD = blue. Box plots in a and b are derived from n = 55 and n = 182 independent samples, respectively. Box plots are displayed at the 25th and 75th percentiles with the median line. Whiskers are drawn to the largest and smallest values that are within 1.5 times the interquartile range from the upper or lower quartile. For observations larger or smaller than this distance, they are shown as observations outside the whiskers.