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. 2021 Apr 19;11:8474. doi: 10.1038/s41598-021-87895-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Discrimination of groups using combination of inflammatory biomarkers in cerebrospinal fluid: Left panel: In an exploratory approach, a sparse canonical correlation analysis (sCCA) was employed to test whether experimental groups could be distinguished based on the overall expression profile of all the markers measured. Right panel: Canonical coefficient scores were calculated and ranked to identify the biomarkers responsible for the difference between groups in the sCCA model.