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. 2021 Apr 19;11:8501. doi: 10.1038/s41598-021-88080-3

Table 2.

Complications and prognosis of all patients in the control and ruxolitinib groups (N = 55).

Control (n = 14) Ruxolitinib (n = 41) χ2 P value
aGVHD (n, %) 3.980 0.046
Yes 7 (50.0) 9 (22.0)
No 7 (50.0) 32 (78.0)
Grade II–IV aGVHD (n, %) 6.132 0.013
Yes 6 (42.9) 5 (12.2)
No 8 (57.1) 36 (87.8)
Grade III-IV aGVHD (n, %) 4.245 0.039
Yes 4 (28.6) 3 (7.3)
No 10 (71.4) 38 (92.7)
cGVHD (n, %) 0.002 0.960
Yes 4 (28.6) 12 (29.3)
No 10 (71.4) 29 (70.7)
Severe cGVHD (n, %) 0.716 0.398
Yes 3 (21.4) 5 (12.2)
No 11 (78.6) 36 (87.8)
Hemorrhagic cystitis (n, %) 0.006 0.937
Yes 7 (50.0) 21 (51.2)
No 7 (50.0) 20 (48.8)
Pulmonary infection (n, %) 0.076 0.783
Yes 9 (64.3) 28 (68.3)
No 5 (35.7) 13 (31.7)
Intestinal infection (n, %) 1.725 0.189
Yes 6 (42.9) 10 (24.4)
No 8 (57.1) 31 (75.6)
EBV infection (n, %) 0.000 0.983
Yes 1 (7.1) 3 (7.3)
No 13 (92.9) 38 (92.7)
CMV infection (n, %) 0.002 0.967
Yes 11 (78.6) 32 (78.0)
No 3 (21.4) 9 (22.0)
Relapse (n, %) 0.352 0.553
Yes 3 (21.4) 6 (14.6)
No 11 (78.6) 35 (85.4)
Death (n, %) 0.487 0.485
Yes 8 (57.1) 19 (46.3)
No 6 (42.9) 22 (53.7)
Nonrelapse mortality (n, %) 0.317 0.574
Yes 6 (42.9) 16 (39.0)
No 2 (14.3) 3 (7.3)

CMV Cytomegalovirus, EBV Epstein-Barr virus, GVHD graft-versus-host disease.