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. 2021 Apr 6;9:659783. doi: 10.3389/fcell.2021.659783

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Copyright © 2021 Wang, Li, Guo, Dong, Liao, Du, Wang, Yin and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of visual function in EXO_PACAP38-treated rats after ONC. (A) F-VEP was recorded at 7 days after injury in normal controls; untreated group; and EXO-, PACAP38-, and EXO_PACAP38-treated groups. (B) Analysis of N2P2 wave at 7 days after injury (n = 4; values are mean ± SEM, one-way ANOVA, *P < 0.05). (C) Analysis of P2-wave latencies at 7 days after injury. No statistical significance in P2-wave amplitudes was observed at 7 days after injury in the EXO_PACAP38-treated group compared with the untreated group (n = 4; values are mean ± SEM, one-way ANOVA, *P < 0.05). (D) F-VEP was recorded at 14 days after injury in normal controls; untreated group; and EXO-, PACAP38-, and EXO_PACAP38-treated groups. (E) Analysis of N2P2 wave at 14 days after injury (n = 4; values are mean ± SEM, one-way ANOVA, **P < 0.01). (F) Analysis of P2-wave latencies at 14 days after injury. Significant improvement in P2-wave latencies was achieved at 14 days after injury in the EXO_PACAP38-treated group compared with the untreated group (n = 4; values are mean ± SEM, one-way ANOVA, *P < 0.05).