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. 2021 Apr 6;9:617589. doi: 10.3389/fcell.2021.617589

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Copyright © 2021 Li, Li, Xie and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Human bone marrow–derived mesenchymal stem cell (hBMSC)–derived exosomes altered T-cell subpopulation in acute graft-versus-host disease. (A) The number of CD3⁺CD8⁺ T cells of blood samples in the control and Msc-exo treated mice. (B) The number of CD3⁺CD4⁺ T cells of blood samples in the control and Msc-exo treated mice. (C) The ratio of CD4⁺ to CD8⁺ T cells in the control and Msc-exo treated mice. *p < 0.05. Data were representative of two to three independent experiments where n = 5 in each group.