Table 1.

Reclassification of patients diagnosed with variants of uncertain significance based on ClinVar data.

BRCA1	58 mutations (n = 278)
Benign/ likely benign	20 mutations (n = 193)
VUS	8 mutations (n = 8)
Conflicting in interpretations of pathogenicity	12 mutations (n = 55)
Pathogenic/ likely pathogenic	4 mutations (n = 6)
Variants not registered in SNP database	14 mutations (n = 16)

BRCA2	91 mutations (n = 453)
Benign/ likely benign	25 mutations (n = 328)
VUS	33 mutations (n = 58)
Conflicting in interpretations of pathogenicity	18 mutations (n = 51)
Pathogenic/ likely pathogenic	2 mutations (n = 3)
Variants not registered in SNP database	13 mutations (n = 13)