FIGURE 5.

Kaplan–Meier survival curves and log-rank test showed significant differences in survival [χ²(2) = 56.505, p < 0.001], when trichotomizing the ALS patients into groups with high (n = 36), intermediate (n = 77), and low (n = 43) CSF NfL concentrations. Estimated marginal means of the previously described analysis of covariance were used for the subdivision of ALS patients into groups with high (Log[NfL] > 4.149), intermediate (3.651 < Log[NfL] < 4.149), and low (Log[NfL] < 3.651) CSF NfL concentrations. Of the 156 ALS patients included in the survival analysis, 97 patients (13 with low, 51 with intermediate, and 33 with high CSF NfL levels) reached the endpoint death or tracheostomy, whereas the remaining 59 patients were censored. ALS, amyotrophic lateral sclerosis; CSF, cerebrospinal fluid; NfL, neurofilament light chain.