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. 2021 Apr 6;9:631931. doi: 10.3389/fcell.2021.631931

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Copyright © 2021 Wang, Shang, Gai, Song, Han, Liu and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SULF2 secreted by HCC cells induced the transformation from HSCs to CAFs. (A) Both RT-PCR and western immunoblotting assays showed that there was more expression of α-SMA, FAP, and POSTN in LX2 cells co-cultured with Hep3B SULF2 cells (LX2 SULF2 cells) than those co-cultured with Hep3B Vector cells (the protein was extracted from total cells). (B) LX2 cells co-cultured with Huh7 Scr shRNA cells expressed more α-SMA, FAP, and POSTN than those with Huh7 SULF2 shRNA cells. Cell fractions: LX2 cells (the protein was extracted from total cells). SULF2, sulfatase 2; HCC, hepatocellular carcinoma; CAF, carcinoma-associated fibroblast.