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. 2021 Apr 6;9:583146. doi: 10.3389/fcell.2021.583146

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Copyright © 2021 Huang, Wang, Chen, Zhong, Gao, Zhang, Niu, Li and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between FXR and SHP/p53 expression. Overexpression of FXR upregulated MDM2 and p53 in cervical cancer cells (A) and xenograft tumors from nude mice, as measured by western blot (B) and immunohistochemistry (C). ^∗P < 0.05 vs. Lenti-Vector group. The knockdown of SHP decreased the protein levels of MDM2 and p53 (D). ^∗P < 0.05 vs. si-NC group.