Table 1.

Prognostic performance of PAM against current monitoring tools.

Univariate analysis
	N. negative/positive	p-value	ROC AUC (95 CI)	Sensitivity	Specificity
Erythrocyte count (Δ/dt)	358/110	0.019	0.57 (0.51–0.62)*	0.47 (0.43–0.52)	0.42 (0.34–0.49)
Hemoglobin (Δ/dt)	372/122	< 0.001	0.62 (0.57–0.66)*	0.47 (0.43–0.51)	0.38 (0.31–0.45)
Leukocyte count (Δ/dt)	366/116	0.039	0.55 (0.49–0.61)	0.52 (0.48–0.56)	0.56 (0.49–0.64)
Thrombocyte count (Δ/dt)	366/116	0.421	0.51 (0.45–0.56)	0.51 (0.47–0.56)	0.54 (0.46–0.61)
Radiological Progression	145/65	< 0.001	0.64 (0.58–0.70)	0.87 (0.82–0.91)	0.42 (0.31–0.52)
Radiological response	145/65	< 0.001	0.66 (0.62–0.69) *	0.69 (0.62–0.75)	0.00 (0.00–0.00)
AI-score (abdomen)	437/117	< 0.001	0.73 (0.69–0.76)	0.60 (0.56–0.64)	0.74 (0.69–0.80)
AI-score (thorax)	1,421/516	< 0.001	0.67 (0.64–0.69)	0.58 (0.56–0.60)	0.71 (0.68–0.74)
Multivariate analysis
	Coefficient	Standard deviation	95 Confidence interval		p-value
Intercept	−1.1010	3.213	−7.398	5.196	0.732
AI-score (abdomen)	−7.9394	1.683	−11.239	−4.640	<0.001
Age	−7.3906	2.699	−12.680	−2.101	0.006
Erythrocyte + hemoglobin (Δ/dt)	−0.2210	2.455	−5.034	4.592	0.928
Leukocyte count (Δ/dt)	10.9735	4.810	1.546	20.401	0.023
Thrombocyte count (Δ/dt)	−0.3935	2.022	−4.357	3.570	0.846
Radiological progression	−3.0030	0.693	−4.361	−1.645	<0.001
Radiological response	> 100	> 100	< −100	> 100	0.999

AUC <0.5 were inverted for readability, indicated by *.