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. 2021 Apr 6;12:639548. doi: 10.3389/fendo.2021.639548

Table 2.

Indications for Liver Biopsy of the ESPGHAN Hepatology Committee.

Approach to Liver Biopsy in Children and Adolescents
1. Assessment of NAFLD in children who have increased risk of NASH and/or advanced fibrosis
2. The exclusion of other treatable disease, only if other non-invasive investigations have not been conclusive
3. Before pharmacological/surgical treatment
4. As part of a structured intervention protocol or clinical research trial