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. 2021 Mar 12;9:622898. doi: 10.3389/fchem.2021.622898

FIGURE 4.

FIGURE 4

Crystal structure of SARS-CoV-2 Mpro in complex with clinically approved antiviral drugs and PanDDA analyzed fragments. (A) Boceprevir (PDB entry: 7K40, 1.35 Å resolution) (B) narlaprevir (PDB entry: 7JYC, 1.79 Å resolution) (C) telaprevir (PDB entry: 7K6D, 1.48 Å resolution) (D) x0397 (PDB entry: 5RGI, 1.57 Å resolution) (E) x2754 (PDB entry: 5RHF, 1.76 Å resolution) and (F) x2705 (PDB entry: 5RH7, 1.71 Å resolution). Residues in the catalytic dyad: His41 is highlighted green and Cys145 is highlighted yellow. The carbon atoms of each drug are highlighted in magneta. All structures described in the figures in this paper are solved by X-ray crystallography.