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. 2021 Apr 6;11:663360. doi: 10.3389/fonc.2021.663360

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Copyright © 2021 Abudureheman, Xia, Li, Zhou, Zheng, Zhou, Shi, Zhu, Yang, Chen, Zheng, Xue, Qing and Duan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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THZ1 perturbs the cellular metabolic pathways of B-ALL cells. (A,B) Principal component analysis and correlation analysis of the RNA-SEQ data in THZ1- and DMSO-treated NALM6 cells. (C,D) Volcano plot and heatmap of differentially expressed genes by a log2-fold change ≥ 1.5 or ≤ −1.5 (p < 0.05) in THZ1- and DMSO-treated NALM6 cells. (E) Pathway analysis of upregulated and downregulated genes (p < 0.05) in THZ1- and DMSO-treated NALM6 cells. (F) KEGG pathway analysis of downregulated metabolic genes (p < 0.05) in THZ1- and DMSO-treated NALM6 cells. (G) KEGG pathway analysis of downregulated metabolic genes (p < 0.05) in THZ1- and DMSO-treated NALM6 cells. (H) Gene set enrichment analysis of the genes related to glucose, amino acid, and nucleotide metabolism. B-ALL cells were treated with THZ1 for 24 h.