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. 2021 Apr 6;11:663360. doi: 10.3389/fonc.2021.663360

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Copyright © 2021 Abudureheman, Xia, Li, Zhou, Zheng, Zhou, Shi, Zhu, Yang, Chen, Zheng, Xue, Qing and Duan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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THZ1 blocks the production of metabolic intermediates in B-ALL cells. (A,B) Correlation analysis and principal component analysis of the metabonomic data in THZ1- and DMSO-treated NALM6 and REH cells. (C,D) Volcano plot of differentially metabolic intermediates by a log2-fold change ≥ 1.0 or ≤ −1.0 (p < 0.05) in THZ1- and DMSO-treated NALM6 and REH cells. (E,F) Heatmap of differentially metabolic intermediates by a log2-fold change ≥ 1.0 or ≤ −1.0 (p < 0.05) in THZ1- and DMSO-treated NALM6 and REH cells. (G,H) Pathway analysis of upregulated and downregulated metabolic intermediates (p < 0.05) in THZ1- and DMSO-treated NALM6 and REH cells. (I,J) Pathway analysis of downregulated metabolic intermediates (p < 0.05) in THZ1- and DMSO-treated NALM6 and REH cells. B-ALL cells were treated with THZ1 for 24 h.