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. 2021 Apr 6;11:663360. doi: 10.3389/fonc.2021.663360

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Copyright © 2021 Abudureheman, Xia, Li, Zhou, Zheng, Zhou, Shi, Zhu, Yang, Chen, Zheng, Xue, Qing and Duan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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THZ1 disturbs the cellular metabolism of B-ALL cells by downregulating c-MYC-mediated metabolic enzymes. (A) Relative mRNA expression of c-MYC was measured by qRT-PCR in THZ1- and DMSO-treated NALM6 and REH cells. (B) Protein expression of c-MYC was determined by Western blot in THZ1- and DMSO-treated NALM6 and REH cells. (C) Relative mRNA expression of GLUT1 was measured by RNA-SEQ in THZ1- and DMSO-treated NALM6 cells. (D,E) Heatmap of glucose, amino acid, and nucleotide metabolism-related genes was analyzed by RNA-SEQ in THZ1- and DMSO-treated NALM6 cells. (F) Protein expression levels of glucose and nucleotide metabolism-related genes, such as HK1, LDHA, and PFKP, were detected by Western blot in THZ1- and DMSO-treated NALM6 and REH cells. B-ALL cells were treated with THZ1 for 24 h. Values were shown as mean ± SEM. ^**p < 0.01, ^***p < 0.001, and ^****p < 0.0001.