Figure 4.

miR-320b inhibits IH-induced lung cancer cell proliferation and invasion by targeting USP37

(A) qRT-PCR evaluating the expression of miR-320b in lung cancer cells under different conditions. (B) Immunoblotting analysis detecting the expression of USP37 in lung cancer cells. (C) Results of EdU proliferation assay measuring lung cancer cell growth. (D) Results of Transwell invasion assay investigating lung cancer cell invasion potency (∗p < 0.05, 6IH + miR-320b mimic + oe-NC versus 6IH + mimic NC + oe-NC; #p < 0.05, 6IH + miR-320b + oe-USP37 versus 6IH + miR-320b + oe-NC). Data are presented as the mean ± standard deviation. Data between two groups were compared using an unpaired t test. Comparisons among multiple groups were performed using one-way ANOVA with Tukey’s post hoc test.