Table 3.
Impact of the methanol extract of C. digyna stems on castor oil incited intraluminal fluid accumulation in mice.
| Treatment | Dose, route (p.o) | MWSIC (g) | % of inhibition | MVSIC (mL) | % of inhibition |
|---|---|---|---|---|---|
| Group-Ⅰ | 1% tween 80-10 mL/kg | 0.60 ± 0.02 | – | 0.48 ± 0.02 | – |
| Group-Ⅱ | Loperamide-3 mg/kg | 0.17 ± 0.09*** | 71.66 | 0.13 ± 0.01*** | 72.91 |
| Group-Ⅲ | MECD-50 mg/kg | 0.53 ± 0.01* | 11.66 | 0.44 ± 0.02 | 8.33 |
| Group-Ⅳ | MECD-100 mg/kg | 0.38 ± 0.02*** | 36.67 | 0.30 ± 0.02** | 37.50 |
| Group-Ⅴ | MECD-200 mg/kg | 0.27 ± 0.01*** | 55.00 | 0.22 ± 0.01*** | 54.16 |
| Group-Ⅵ | MECD-400 mg/kg | 0.17 ± 0.02*** | 71.66 | 0.17 ± 0.01*** | 64.58 |
The values are expressed as mean ± SEM (n = 6); One-way analysis of variance (ANOVA) suggested by Dunnett's test. Significant (*p < 0.05, **p < 0.01, ***p < 0.001) compared with the control sample. MECD = methanol extract of C. digyna. MWSIC = mean weight of the small intestinal content, MVSIC = mean volume of the small intestinal content.