TABLE 7.

Comparison between the low-risk (n = 2516) and high-risk (n = 5287) subgroups in AREDS and AREDS2 data

	Low-risk subgroup Mean (SD) or n (%) or risk allele frequency	High-risk subgroup Mean (SD) or n (%) or risk allele frequency	p-values
Top predictors
Age	66.1 (5.4)	71.1 (5.9)	<2.2 × 10−16
Smoke			<2.2 × 10−16
Never	1343 (53%)	2280 (43%)
Former	1088 (43%)	2664 (50%)
Current	85 (3%)	343 (6%)
Education
≤ high school	625 (25%)	1744 (33%)	3.2 × 10−13
> high school	1891 (75%)	3543 (67%)
rs10922098 (CFH)	0.34	0.61	<2.2 × 10−16
rs11200638 (HTRA1)	0.17	0.39	<2.2 × 10−16
rs12987936 (CROCC2)	0.18	0.18	0.35
rs147518956 (ADAMTS12)	0.27	0.32	1.8 × 10−13
rs200880300 (SV2C)	0.04	0.06	1.0 × 10−3
rs2186849 (LOC105371956)	0.47	0.50	1.0 × 10−3
rs3750847 (ARMS2)	0.17	0.40	<2.2 × 10−16
rs4044578 (CFHR4)	0.33	0.62	<2.2 × 10−16
Other characteristics
GRS	0.94 (0.13)	1.07 (0.13)	<2.2 × 10−16
Gender
Female	1439 (57)	3027 (57)	0.98
Male	1077 (43)	2260 (43)
Baseline severity	3.0 (2.3)	4.7 (2.4)	<2.2 × 10−16

Abbreviations: AREDS, age-related eye disease studies; GRS, genetic risk score.