Table 3.

Correlation between changes in bile acids and changes in Pro-C3 in the pooled NASH and PSC populations.

Percent change in bile acids from baseline to week 12	Percent change in Pro-C3 from baseline to week 12
	rho	p value
Primary bile acids
Glycine-conjugated primary bile acids
GCA (μmol/L)	0.33	<0.001
GCDCA (μmol/L)	0.25	<0.001
Taurine-conjugated primary bile acids
TCA (μmol/L)	0.16	0.02
TCDCA (μmol/L)	0.06	0.38
Unconjugated primary bile acids
CA (μmol/L)	0.23	0.001
CDCA (μmol/L)	0.17	0.01
Secondary bile acids
Glycine-conjugated secondary bile acids
GDCA (μmol/L)	0.34	<0.001
GLCA (μmol/L)	0.30	<0.001
Taurine-conjugated secondary bile acids
TDCA (μmol/L)	0.31	<0.001
TLCA (μmol/L)	-0.01	0.86
Unconjugated secondary bile acids
DCA (μmol/L)	0.36	<0.001
LCA (μmol/L)	0.30	<0.001

Data are presented as correlation coefficients. Values of p by Spearman’s method.

CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; GCA, glycocholic acid; GCDCA, glycochenodeoxycholic acid; GDCA, glycodeoxycholic acid; GLCA, glycolithocholic acid; LCA, lithocholic acid; TCA, taurocholic acid; TCDCA, taurochenodeoxycholic acid; TDCA, taurodeoxycholic acid; TLCA, taurolithocholic acid.