Table 2. Outcomes of DOAC vs DOAC Plus ASA.
| Outcome | No. per 100 patient-years (95% CI) | P value | |
|---|---|---|---|
| DOAC (n = 1047) | DOAC+ASA (n = 1047) | ||
| New thrombosis | 2.30 (1.98-2.59) | 2.50 (2.20-2.83) | .80 |
| Ischemic/embolic stroke | 0.90 (0.71-1.08) | 0.70 (0.55-0.90) | .31 |
| TIA | 0.20 (0.10-0.27) | 0.10 (0.05-0.20) | .58 |
| PE | 0.20 (0.14-0.33) | 0.20 (0.09-0.26) | .67 |
| DVT | 0.40 (0.28-0.53) | 0.90 (0.70-1.07) | .07 |
| MI | 0.10 (0.05-0.20) | 0.10 (0.02-0.12) | .51 |
| New bleed | 26.00 (25.05-27.06) | 31.60 (30.54-32.75) | .009 |
| Major | 3.59 (3.23-3.98) | 4.95 (4.52-5.41) | .09 |
| Fatal | 0.06 (0.02-0.13) | 0.05 (0.02-0.12) | .82 |
| Intracranial or intraspinal | 0.39 (0.28-0.53) | 0.33 (0.23-0.46) | .75 |
| Life threatening | 1.05 (0.86-1.27) | 1.42 (1.20-1.67) | .38 |
| Nonmajor | 21.70 (20.77-22.60) | 26.10 (25.14-27.15) | .02 |
| ED visit | 11.50 (10.84-12.18) | 13.80 (13.05-14.52) | .14 |
| For bleeding | 10.40 (9.77-11.04) | 13.00 (12.31-13.74) | .08 |
| For clotting | 1.30 (1.06-1.51) | 0.80 (0.65-1.02) | .12 |
| Hospitalization | 6.50 (6.03-7.04) | 9.10 (8.51-9.70) | .02 |
| For bleeding | 5.30 (4.87-5.78) | 8.20 (7.62-8.75) | .006 |
| For clotting | 1.20 (1.01-1.46) | 0.90 (0.75-1.14) | .31 |
| Death | 3.40 (3.02-3.75) | 3.80 (3.39-4.16) | .76 |
Abbreviations: ASA, acetylsalicylic acid or aspirin; DOAC, direct oral anticoagulant; DVT, deep vein thrombosis; ED, emergency department; MI, myocardial infarction; PE, pulmonary embolism; TIA, transient ischemic attack.