TABLE 1.

Cases of necrotizing fasciitis associated with external beam radiation therapy

Author	Year	Country	Location (necrotizing fasciitis within the irradiation fields)	Age(yr)	Sex	Risk factors	Time period between radiation and onset of fasciitis	Comorbidities	Microbiology (tissue culture)	Outcome
Maluf et al29	2007	Brazil	Neck	64	M	None	9 mo	Squamous cell carcinoma of the oropharynx chemotherapy and radiotherapy 9 mopreviously	Streptococcus pyogenes	Survived
Miyagawa et al30	2005	Japan	Penis and left upper limb	60	M	Mild and persistent edema of the penile and scrotal skin since radiotherapy	7 yr	Testicular cancer highdose chemotherapy (HDCT) andradiotherapy 7 yr previously	S. pyogenes	Died
Mortimore and Thorp32	1998	South Africa	Neck and chest	56	M	None	6 yr	Squamous cell carcinoma of the mouth	Group A p-haemolytic Streptococcus	Survived
Mortimore and Thorp32	1998	South Africa	Neck	52	M	Osteoradionecrosis of the mastoid portion of the temporal bone for 10 yr before presentation	10 yr	Squamous cell carcinoma of tongue, alcohol abuse	Streptococcus milleri and numerous anaerobic bacteria	Survived
Livengood et al31	1991	USA	Pelvis, inguinal area	51	F	Total abdominal hysterectomy and bilateral salpingo-oophorectomy36 d before onset offasciitis	56 d	Obesity, diabetes, stage IV uterine mullerian tumor, radiotherapy	Proteus mirabilis and numerous anaerobic bacteria	Died
Livengood et al31	1991	USA	Pelvis	68	F	Radiation proctosigmoiditis	12 mo	Diabetes, stage III adenocarcinoma of cervix, advanced age	Escherichia coli, Clostridium spp.	Died
Husseinzadeh etAl333	1984	USA	Buttock, pelvis	25	F	Radiation dermatitis	10 d	Invasive cervical cancer, radiotherapy, methotrexate	Anaerobic bacteria from wound culture	Survived
Krespi et al34	1981	USA	Neck	60	M	Osteoradionecrosis of the temporal bone	9 mo	Squamous cell carcinoma of the middle ear, radiotherapy 9 mopreviously	P. mirabilis, Enterococcus, and E. coli	Survived