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. 2021 Apr 20;35(11):3113–3126. doi: 10.1038/s41375-021-01222-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Diffuse BM infiltration by leukaemic cells. Dysplastic megakaryocytes are also present (arrow). B Mononucleated blasts and dysplastic megakaryocytes (arrow) express cytoplasmic NPM1 (APAAP immunostaining, x400). C Sanger sequencing of exon 11 showing a heterozygous 8 nucleotides insertion leading to a stop codon at amino acid 275. D Schematic representation of the new mutant protein (Mut) compared with the wild-type (WT). Analysis of the new protein sequence predicted a truncated protein (274 aa length), with a newly acquired NES motif (VxxxFxxLxIx). Both proteins are recognized by the anti-NPM1, Clone 376 mAb: monoclonal antibody.