Table 2.

Association between lifestyle factors and AD biomarkers

	Current smoking		P*	P#
	Yes (n = 220)	No (n = 888)
CSF Aβ42	162.25 ± 71.75	169.01 ± 81.40	0.47	0.17
CSF tau	170.81 ± 70.35	171.43 ± 77.54	0.78	0.29
CSF p-tau	36.57 ± 8.57	36.89 ± 9.23	0.83	0.47
	Alcohol consumption
	Harmful drinking (n = 157)	No or moderate drinking (n = 951)
CSF Aβ42	178.53 ± 94.72	165.82 ± 76.65	0.35	0.44
CSF tau	175.84 ± 80.03	170.55 ± 75.48	0.63	0.12
CSF p-tau	37.11 ± 10.00	36.79 ± 8.95	0.97	0.35
	Absence of social isolation
	No (n = 240)	Yes (n = 868)
CSF Aβ42	175.89 ± 89.94	165.33 ± 76.30	0.27	0.19
CSF tau	188.17 ± 76.40	166.67 ± 75.44	< 0.01	< 0.01
CSF p-tau	39.11 ± 9.09	36.21 ± 9.01	< 0.01	< 0.01
	Regular physical activity
	No (n = 833)	Yes (n = 275)
CSF Aβ42	163.96 ± 76.65	178.96 ± 87.03	0.03	0.01
CSF tau	173.73 ± 78.20	164.03 ± 69.15	0.10	0.04
CSF p-tau	37.25 ± 9.32	35.57 ± 8.28	0.01	< 0.01

*Unadjusted

^#Adjusted for age, sex, educational level, and APOE ε4 status